Cancer and Reproductive Antigens
CTA = Cancer Antigens ∩ Reproductive Antigens.
Target candidates = Cancer Antigens ∪ Reproductive Antigens.
Rebuilt catalog: oncoref.target-selection.2026-11-09.1.
632 CTA, 250 Cancer Antigen only, 28 Reproductive Antigen only, 724 Other, 18,259 Unsafe.
Filterable protein table, measurements and category changes.
The released 1.36.0 catalog remains a separate snapshot under its earlier policy.
One shared eligibility screen
Accepted normal-tissue or applicable clinical exclusion → Unsafe.
Required coverage, identity, translation or unresolved evidence → Other:Review.
Nested or Unsafe-contained sequence → Other:Sequence.
The remaining proteins enter the two independent association checks.
The same defined Disposable and reproductive compartment allowances apply to both
sets. Immune or other protected cells do not inherit an allowance from their organ.
Cancer evidence
Let N be the highest qualified nonexempt normal measurement in a complete, compatible
comparison panel. Two independent patients each need T ≥1 and T >N; alternatively,
one tumor needs T ≥5 × max(N, 1). Sample quality and exact protein identity must pass.
| Normal maximum N | Two independent tumors | One tumor |
|---|
| 0 | ≥1 each | ≥5 |
| 0.4 | ≥1 each | ≥5 |
| 1 | >1 each | ≥5 |
| 3 | >3 each | ≥15 |
| 8 | >8 each | ≥40 |
Do not divide tumor TPM by an unrelated normal nTPM or CP10K maximum. Record the
comparison methods, normal contexts, source statistics and sample identities.
Missing required normal data leave the comparison unassessed. All other normal panels
continue to enforce their exclusions.
Wang et al., 2018.
Reviewed reliable tumor protein is a separate positive evidence route. Qualitative
staining does not supply an RNA fold change. A high tumor value never cancels a normal exclusion.
Reproductive and developmental evidence
Adult reproductive, placental, extraembryonic, embryonic and fetal associations count.
Use ≥1 native TPM/nTPM with the existing cell/read support, or reliable mapped protein
evidence. Record the actual branch and stage. The old adult reproductive concentration
score becomes descriptive; it is not an admission gate.
The 1-unit detection convention is distinct from protein production or antigen
presentation. HPA methods.
Published target support
A curated target nomination adds supporting evidence. Preserve the exact protein–paper
link and what it establishes: nomination, biology, tumor expression, protein identity,
immune recognition, or normal-tissue counterevidence. Source-wide roles do not turn
every gene in a paper into a target.
Core papers cover the catalog efficiently; supplementary papers retain independent
experiments, identity limits and counterevidence. Both remain available through
cta_literature.attestations(), including links attached to Other and Unsafe proteins.
Read the decision precisely
“Cancer Antigen only” and “Reproductive Antigen only” describe membership in one qualified
set. They do not establish absence everywhere else. Unassessed associations stay visible.
Target candidates is the union's name; it does not assert clinical safety.
Full definitions and API ·
Machine-readable contract