{
  "policy_id": "oncoref.target-selection.2026-11-09.1",
  "status": "research_catalog_rebuilt",
  "species": "human",
  "categories": [
    "CTA",
    "Cancer Antigen only",
    "Reproductive Antigen only",
    "Other",
    "Unsafe"
  ],
  "shared_checks": [
    "normal_screen_pass",
    "required_coverage_complete",
    "identity_translation_pass",
    "evidence_resolved",
    "sequence_pass"
  ],
  "sets": {
    "Cancer Antigens": "eligible AND cancer evidence qualifies",
    "Reproductive Antigens": "eligible AND reproductive/developmental evidence qualifies",
    "CTA": "Cancer Antigens INTERSECTION Reproductive Antigens",
    "Target candidates": "Cancer Antigens UNION Reproductive Antigens"
  },
  "precedence": [
    "Unsafe",
    "Other:Review",
    "Other:Sequence",
    "set memberships"
  ],
  "other_subtypes": {
    "Review": "Required evidence is missing, unresolved, or fails a shared admission check.",
    "Sequence": "Nested protein without independent support or >=95% Unsafe 9-mer containment.",
    "Expression": "Shared checks pass; neither positive expression route qualifies."
  },
  "cancer_rna": {
    "detection_floor": 1.0,
    "independent_participants_required": 2,
    "repeated_rule": "T >= 1 AND T > N in at least two independent participants",
    "single_tumor_fold": 5.0,
    "single_rule": "T >= 5 * max(N, 1) in at least one qualified tumor sample",
    "normal_reference": "Maximum QC-passing, identity-resolved measurement in the declared compatible normal panel, excluding specifically allowed Disposable and reproductive compartments.",
    "comparability": "One documented comparison scale and complete required normal contexts. Equal unit names alone do not establish comparability. No TPM/nTPM/pTPM/CP10K pooling.",
    "missing_reference": "unassessed, never zero",
    "alternative": "Reviewed reliable tumor protein with exact identity and source scope."
  },
  "reproductive_evidence": {
    "branches": [
      "adult reproductive",
      "placental",
      "extraembryonic",
      "embryonic",
      "fetal"
    ],
    "rna_detection_floor": 1.0,
    "bulk": "Mapped human reproductive compartment >=1 native TPM/nTPM.",
    "cell": "Mapped reproductive cells >=1 native TPM/nTPM and >=20 reads.",
    "developmental": "Human stage/lineage mean >=1 TPM, >=20 cells, >=5 cells at >=1 TPM, and >=10% cells at >=1 TPM. Retain embryos, donors and stage.",
    "protein": "Reliable mapped reproductive IHC or reviewed human reproductive protein.",
    "concentration": "Descriptive measurement; not an admission gate for either set."
  },
  "shared_normal_policy": {
    "policy_id": "oncoref.cta-selection.2026-11-08.1",
    "scope": "Normal assessment only; legacy cancer, reproductive and concentration gates excluded.",
    "allowances": "Same resolved reproductive and Disposable compartment allowances for both sets. Immune, endothelial and other protected cells do not inherit an organ's allowance.",
    "threshold_interpretation": "RNA/IHC cutoffs are screening conventions, not measured injury thresholds. Negative IHC does not establish a calibrated safety margin."
  },
  "translation": "Qualifying coding reference or supported noncanonical ORF plus complete approved MANE-first/canonical representative; resolve conflicting coding evidence. Experimental protein detection is retained separately.",
  "published_target_support": "Positive evidence annotation for a curated, exact-scope target nomination. Preserve every protein-paper link and its attested claim; biology or background-table coverage alone is not a target nomination. Publication cannot override an exclusion or hold.",
  "only_meaning": "Membership in one qualified set, not proven absence from the other context."
}