Rebuilt antigen catalog
19,893 proteins assessed under oncoref.target-selection.2026-11-09.1. Identical selected reference proteins are counted together; every member locus remains listed.
Draft: expression support remains under review. These counts are outputs of the screening rules. The original 250-protein audit documents cohort dependence, low tumor abundance, specialized normal compartments and the corrected publication flags.
| Exclusive category | Proteins | With a curated target nomination |
|---|
| CTA | 638 | 408 |
| Cancer Antigen only | 260 | 24 |
| Reproductive Antigen only | 22 | 4 |
| Other | 714 | 52 |
| Unsafe | 18,259 | 1,745 |
Cancer Antigens: 898 · Reproductive Antigens: 660 · CTA intersection: 638 · Target candidates union: 920.
Other: 659 review, 40 sequence, 15 expression. Of the 22 Reproductive Antigens only, 15 have potentially qualifying repeated tumor measurements with unresolved patient identities. The remaining 7 do not meet either cancer RNA rule in the measured samples.
The shared eligibility screen leaves 957 proteins. Cancer RNA needs two confirmed independent patients each ≥1 TPM and above the eligible normal maximum N, or one sample ≥5 × max(N, 1). Reproductive/developmental RNA association uses ≥1 with the established read/cell support. The reproductive concentration score no longer excludes candidates.
The comparison uses native gene TPM with resolved identities and source quality checks. N is the maximum supported tissue/cell summary, not the largest value in every healthy donor. Cross-study batch effects are not corrected. Other assay scales retain their independent normal-exclusion rules. Exact comparison scope · Cross-study methods.
NUTM coverage: the stored UNC three-sample matrix fails the nonnegative-TPM check and contributes no qualifying samples. Its failed source remains in the coverage ledger; #604 and #665 track the repair. No raw reads were re-quantified for this rebuild.
Changes from the released catalog
| Released category | New category | Proteins |
|---|
| CTA | Other | 7 |
| CTA | Reproductive Antigen only | 20 |
| Other | CTA | 58 |
| Other | Cancer Antigen only | 260 |
| Other | Reproductive Antigen only | 2 |
All changed proteins and their evidence · Counts · All member genes · Full protein decisions
Category downloads: CTA · Cancer Antigen only · Reproductive Antigen only · Other · Unsafe.
Find a protein
“Only” describes qualified set membership. Missing evidence is shown as —, never zero. The cancer values are recalculated for the 957 proteins passing shared eligibility; other rows retain their exclusion or review decision.
All comparison normal measurements · Tumor witnesses · Every retained protein–paper claim · Input hashes · Ontology figures and rules