Shared screen and antigen sets

CTA = Cancer Antigens ∩ Reproductive Antigens. Their union is Target candidates. Both sets require the same normal-expression, coverage, translation and sequence checks.

The full policy definition gives the exact thresholds, source requirements, API and paper roles. The rebuilt catalog contains 882 Cancer Antigens and 660 Reproductive Antigens: 632 CTAs in their intersection and 910 Target candidates in their union. The 1.36.0 catalog retains its prior policy and counts.

Evidence	Role
Accepted normal-tissue or applicable clinical exclusion	Establishes Unsafe, regardless of other evidence
Complete shared eligibility checks	Required for both antigen sets; not being Unsafe alone is insufficient
Qualifying tumor evidence	Establishes Cancer Antigen membership after the shared screen
Reproductive or developmental association	Establishes Reproductive Antigen membership after the shared screen
Curated published target nomination	Additional supporting evidence, with the exact protein–paper claim retained
Reproductive concentration	Descriptive measurement under the next policy

Reproductive includes adult reproductive, placental, extraembryonic, embryonic and fetal contexts. Neither publication nor a high tumor value overrides a normal exclusion. An unassessed association remains visible; missing required normal coverage blocks both memberships.

Proteins with identical selected reference sequences are counted together, with every member locus retained. This is not an inventory of all alternative isoforms or modified proteoforms. Human evidence does not transfer to another species through orthology.