Rebuilt antigen catalog
Draft: tumor-source comparability and specialized normal/developmental coverage remain under review. Scrutiny of the original 250 Cancer Antigens only.
638 CTA, 260 Cancer Antigen only, 22 Reproductive Antigen only, 714 Other and 18,259 Unsafe.
Filterable protein table · All category changes · Exact comparison scope
Cancer Antigens include 898 proteins; Reproductive Antigens include 660. Their intersection is CTA and their union contains 920 Target candidates.
Other contains 659 review, 40 sequence, 15 expression. A curated published target nomination is retained for 408 CTAs and 24 Cancer Antigens only. Broader paper coverage also includes biology, normal-expression findings and other evidence.
Category changes
| Released category | Rebuilt category | Proteins |
|---|---|---|
| CTA | CTA | 580 |
| CTA | Other | 7 |
| CTA | Reproductive Antigen only | 20 |
| Other | CTA | 58 |
| Other | Cancer Antigen only | 260 |
| Other | Other | 707 |
| Other | Reproductive Antigen only | 2 |
| Unsafe | Unsafe | 18259 |
New CTAs: AMELY, H2BW2, KRT37, UCP1, ANKRD60, SRMS, OR1E2, GALR3, OCM2, TTLL8, CIB3, POTED, OR2B2, PROKR1, HOXD12, DEFB125, OR52D1, MAGEB17, DGAT2L6, MROH2A, SPATA31A6, AADACL3, HUS1B, OR14A16, OR51C1, KRTAP4-1, GLYATL3, KRTAP5-10, MAS1L, ARSH, KRTAP19-8, KRTAP20-4, TRIM64C, ZNF705D, DEFB115, TRIM51G, ZNF816-ZNF321P, SUPT20HL1, RAB6D, PRR23C, KRTAP5-7, ENSG00000249773, KRTAP5-9, ENSG00000255432, ENSG00000255835, KDM4F, ENSG00000258691, ENSG00000267140, SPATA31A3, SPATA31A7, SPATA31A5, ENSG00000279983, RPS4Y2, FAM240B, OOSP1, OOSP3, ENSG00000285566, POTEB/2.
Former CTAs now requiring review: CALHM3, TAF11L12, TRIM75, TAF11L14, PRAMEF18, TAF11L11, TAF11L13.
Reproductive Antigens only
15 have potentially qualifying tumor measurements but unresolved patient independence; none reaches the single-sample threshold. The remaining 7 do not meet either cancer RNA rule.
| Protein | Tumor maximum TPM | Normal comparison TPM | Cancer assessment |
|---|---|---|---|
| SLC25A52 | 5.58 | 2.97 | Patient identity unresolved |
| ZSWIM2 | 2.74 | 1.52 | Patient identity unresolved |
| GARIN3 | 6.5 | 2.07 | Patient identity unresolved |
| CDY1 | 1.6 | 0 | Below cancer rule |
| CDY1B | 0.3 | 0.1 | Below cancer rule |
| MAGEB5 | 2.09 | 0.0392 | Patient identity unresolved |
| FAM47B | 2.25 | 0 | Patient identity unresolved |
| VN1R2 | 12.3 | 7.79 | Patient identity unresolved |
| OR8G1 | 2.69 | 2.5 | Below cancer rule |
| DEFB113 | 2.27 | 0 | Patient identity unresolved |
| ZNF705B | 3.78 | 0 | Patient identity unresolved |
| OR5H1 | 1.4 | 2.3 | Below cancer rule |
| FAM237A | 7.8 | 2.26 | Patient identity unresolved |
| H2AL1Q | 4.02 | 2.6 | Patient identity unresolved |
| P3R3URF | 16.5 | 3.4 | Patient identity unresolved |
| PTTG1IP2 | 3.23 | 0.3 | Patient identity unresolved |
| ENSG00000274944 | 13.5 | 2.8 | Patient identity unresolved |
| CCDC201 | 5.38 | 1.1 | Patient identity unresolved |
| HSFX3 | 4.88 | 1.8 | Patient identity unresolved |
| MSANTD5 | 3.43 | 2.2 | Below cancer rule |
| CIMIP3 | 1.2 | 0.2 | Below cancer rule |
| ENSG00000289809 | 0.0679 | 4.5 | Below cancer rule |
Evidence and reproduction
The comparison uses source-native TPM and maxima of supported tissue/cell summaries. It does not correct cross-study batch effects. NUTM's stored three-sample matrix fails the nonnegative-TPM check and is listed in the coverage ledger.
Full protein decisions · All member genes · Normal comparison values · Tumor witnesses · Paper claims · Input hashes.
The pinned HPA download receipt supplies exact URLs, paths and SHA-256 hashes for the newly retrieved native-TPM tables. With the pinned source files in the paths listed in inputs.json, run:
python scripts/rebuild_target_catalog.py
python scripts/render_target_catalog.py
python scripts/build_target_selection_report.py
The builder verifies the pinned tumor matrices, re-resolves source identities and assesses all proteins. Temporary tumor matrices stay outside the published report. The new catalog is available through target_selection.results(); the cta_selection API and existing sequence downloads retain the 1.36.0 snapshot.