Rebuilt antigen catalog

19,893 proteins assessed under oncoref.target-selection.2026-11-10.1. Identical selected reference proteins are counted together; every member locus remains listed.

These counts are outputs of screening rules, not validated tumor antigens. Rare normal-cell RNA is graded per adult donor; single-molecule cells never change a category, and every signal ends as established or dismissed with its reason. Literature review of the dismissed and released proteins. Donor-level evidence · Every change from the 2026-11-09 draft · Earlier 250-protein audit.

Other: 693 review, 42 sequence, 15 expression. Of the 31 Reproductive Antigens only, 22 have potentially qualifying repeated tumor measurements with unresolved patient identities. The remaining 9 do not meet either cancer RNA rule in the measured samples.

The shared eligibility screen leaves 939 proteins. Cancer RNA needs two confirmed independent patients each ≥1 TPM and above the eligible normal maximum N, or one sample ≥10 × max(N, 1). The highest tumor, reproductive or developmental value must exceed every measured nonreproductive and Disposable value, with Disposable expression at most 32 TPM and 32 nTPM. Reproductive/developmental RNA association uses ≥1 with the established read/cell support. The reproductive concentration score no longer excludes candidates.

The comparison uses native gene TPM with resolved identities and source quality checks. N is the maximum supported tissue/cell summary, not the largest value in every healthy donor. Cross-study batch effects are not corrected. Other assay scales retain their independent normal-exclusion rules. Exact comparison scope · Cross-study methods.

NUTM coverage: the stored UNC three-sample matrix fails the nonnegative-TPM check and contributes no qualifying samples. Its failed source remains in the coverage ledger; #604 and #665 track the repair. No raw reads were re-quantified for this rebuild.

Changes from the released catalog

All changed proteins and their evidence · Counts · All member genes · Full protein decisions

Category downloads: CTA · Cancer Antigen only · Reproductive Antigen only · Other · Unsafe.

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“Only” describes qualified set membership. Missing evidence is shown as —, never zero. The cancer values are recalculated for the 939 proteins passing shared eligibility; other rows retain their exclusion or review decision.

All comparison normal measurements · Tumor witnesses · Every retained protein–paper claim · Input hashes · Ontology figures and rules