The Personalized Immunotherapy Research Lab (PIRL) is a multi-investigator research group at the University of North Carolina’s School of Medicine, whose members bring together expertise in immunology, genomics, oncology, and machine learning. We work on developing cancer immunotherapies that use a patient’s immune system to attack tumor-specific targets. We are committed to open science through building open source research software, making experimental data unconditionally available, and disseminating results quickly through blog posts and preprints.