{
  "policy_id": "oncoref.cta-selection.2026-11-08.1",
  "input_records": 19893,
  "counts": {
    "Unsafe": 18259,
    "Other": 1027,
    "CTA": 607
  },
  "restored_records": 260,
  "restored_classifications": {
    "Other:Translation": 248,
    "Unsafe": 12
  },
  "existing_classification_changes": 452,
  "restored_historical_exclusions_reassessed": [
    {
      "protein_group_label": "P2RX5-TAX1BP3",
      "historical_pre_diffuseness_Unsafe_reasons": "DICE immune",
      "classification": "Other:Translation"
    },
    {
      "protein_group_label": "ENSG00000258461",
      "historical_pre_diffuseness_Unsafe_reasons": "DICE immune",
      "classification": "Other:Translation"
    }
  ],
  "stored_zero_rna_screen": {
    "cancer_present_required_bulk_complete": 19341,
    "adult_and_reproductive_bulk_zero": 40,
    "also_developmental_measured": 22,
    "developmental_measurement_missing": 18,
    "also_developmental_zero": 0,
    "also_no_recorded_adult_protein": 0,
    "interpretation": "Stored RNA summary values equal zero; no claim of whole-protein absence or exhaustive normal-cell coverage."
  },
  "preliminary_expression_profile": {
    "matches": 66,
    "classification_counts": {
      "Other:Nonreproductive": 55,
      "Unsafe": 6,
      "Other:Translation": 5
    },
    "disposition_counts": {
      "normal_coverage_review_required": 40,
      "normal_evidence_hold": 15,
      "excluded_by_normal_evidence": 6,
      "translation_review": 5
    },
    "interpretation": "Existing numerical screen: replicated tumor RNA at least 10 TPM in two samples (or reviewed tumor protein), measured adult RNA below nominal 2-unit assay floors, no positive adult protein call in the profile's measurement inputs, measured developmental lineage means below 2 TPM, and no qualifying reproductive/developmental association. Curated knowledge and rare-cell counterevidence is assessed separately and overrides the screen."
  },
  "limitations": [
    "Required bulk coverage does not establish coverage of every cell type, age, physiological state or protein assay.",
    "Routine tissue summaries and developmental lineage means are not maxima across all donors or individual cells.",
    "Small positive developmental RNA values can reflect assay/mapping uncertainty; stored-zero screening is not a biological detection limit.",
    "Missing measurements are reported as gaps, never imputed to zero.",
    "No numerical RNA profile establishes translation, HLA presentation, receptor specificity or clinical safety."
  ]
}