{"version":"2026-11-06.1","scope":"Supplementary-table matches for two additional cancer–embryonic program catalogs. These proposals are separate from the 15 nomination papers used in release 1.31.0.","catalogs":[{"id":"chew2019","citation":"Chew et al., 2019","title":"DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6736738/","catalog":"Table S3: high-confidence DUX4 targets","model":"DUX4-induced gene program evaluated in human cancers; target definition also used induced myoblast experiments.","sources":[{"url":"https://ars.els-cdn.com/content/image/1-s2.0-S1534580719305295-mmc4.xlsx","sha256":"4a176f519ae81388881b0a0c459725635774684eda0ba3b28de91c3c440cfb65"},{"url":"https://ars.els-cdn.com/content/image/1-s2.0-S1534580719305295-mmc2.xlsx","sha256":"b8ae23bd27e6039abb2efb4a1d987fcceabe244d4e7d77e61d9f0230d7aedd6f"}],"matches":[{"protein":"DUXA","entity_id":"PEG:46851e6f1fed76681cb5","gene_id":"ENSG00000258873","source_symbol":"DUXA","source_gene_id":"ENSG00000258873","sheet":"Table S3","row":6,"match_method":"Ensembl ID"},{"protein":"DUXB","entity_id":"PEG:d7c58dfc108d629cedf9","gene_id":"ENSG00000282757","source_symbol":"DUXB","source_gene_id":"DUXB","sheet":"Table S3","row":7,"match_method":"Exact symbol"},{"protein":"LEUTX","entity_id":"PEG:a4d1a78a6bc4d94dfff5","gene_id":"ENSG00000213921","source_symbol":"LEUTX","source_gene_id":"ENSG00000213921","sheet":"Table S3","row":11,"match_method":"Ensembl ID"},{"protein":"PRAMEF25/6","entity_id":"PEG:e04fe268186dedc0faed","gene_id":"ENSG00000229571","source_symbol":"WI2-2994D6.2","source_gene_id":"ENSG00000229571","sheet":"Table S3","row":40,"match_method":"Ensembl ID"}],"note":"PRAMEF25 matches the historical WI2-2994D6.2 entry by Ensembl ID and is one member of the shared PRAMEF25/6 protein. DUXB matches by symbol; its source Gene ID is also DUXB. The paper reports DUXB expression in healthy tissues.","interpretation":"Add as a cancer–embryonic program catalog, preserving each gene’s normal-expression findings.","screen_table":{"total_gene_rows":12697,"overlapping_gene_rows":74,"interpretation":"Table S1 is the full cancer-specificity scoring table. Its 74 matches are measured genes, not 74 CTA nominations."},"matched_proteins":4},{"id":"smith2023","citation":"Smith et al., 2023","title":"DUX4 expression in cancer induces a metastable early embryonic totipotent program","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10578318/","catalog":"Table S3A: zygotic gene activation and eight-cell-like gene sets","model":"Single-cell RNA sequencing of KLE and SUSA cancer cell lines using published zygotic gene activation and eight-cell-like gene sets.","sources":[{"url":"https://ars.els-cdn.com/content/image/1-s2.0-S2211124723011257-mmc4.xlsx","sha256":"70fbf0881a6ea959d28ed96f64c78bbd8133790b51c341a362ce86cde36a0394"}],"matches":[{"protein":"DUXA","entity_id":"PEG:46851e6f1fed76681cb5","gene_id":"ENSG00000258873","source_symbol":"DUXA","sheet":"A","row":6,"column":"ZGA genes","match_method":"Exact symbol"},{"protein":"LEUTX","entity_id":"PEG:a4d1a78a6bc4d94dfff5","gene_id":"ENSG00000213921","source_symbol":"LEUTX","sheet":"A","row":9,"column":"ZGA genes","match_method":"Exact symbol"},{"protein":"TAF11L12","entity_id":"PEG:fdd7f0c5ad8fcef88b57","gene_id":"ENSG00000249156","source_symbol":"TAF11L12","sheet":"A","row":20,"column":"ZGA genes","match_method":"Exact symbol"},{"protein":"MBD3L2B","entity_id":"PEG:c5ea92999c5095d9ede4","gene_id":"ENSG00000196589","source_symbol":"MBD3L2B","sheet":"A","row":9,"column":"8C genes","match_method":"Exact symbol"},{"protein":"OR10G3","entity_id":"PEG:4e6ed0a98e0f954e4366","gene_id":"ENSG00000169208","source_symbol":"OR10G3","sheet":"A","row":157,"column":"8C genes","match_method":"Exact symbol"},{"protein":"LEUTX","entity_id":"PEG:a4d1a78a6bc4d94dfff5","gene_id":"ENSG00000213921","source_symbol":"LEUTX","sheet":"A","row":186,"column":"8C genes","match_method":"Exact symbol"},{"protein":"ZNF280A","entity_id":"PEG:71fe1f30ebae17ffbd03","gene_id":"ENSG00000169548","source_symbol":"ZNF280A","sheet":"A","row":301,"column":"8C genes","match_method":"Exact symbol"},{"protein":"ZNF878","entity_id":"PEG:f9a42776af304f6808d7","gene_id":"ENSG00000257446","source_symbol":"ZNF878","sheet":"A","row":421,"column":"8C genes","match_method":"Exact symbol"},{"protein":"DUXA","entity_id":"PEG:46851e6f1fed76681cb5","gene_id":"ENSG00000258873","source_symbol":"DUXA","sheet":"A","row":494,"column":"8C genes","match_method":"Exact symbol"},{"protein":"C19orf85","entity_id":"PEG:239b064b509fe82b6379","gene_id":"ENSG00000283567","source_symbol":"C19orf85","sheet":"A","row":573,"column":"8C genes","match_method":"Exact symbol"},{"protein":"CPHXL","entity_id":"PEG:8379cf8330d2c11fd9d7","gene_id":"ENSG00000283755","source_symbol":"CPHXL","sheet":"A","row":659,"column":"8C genes","match_method":"Exact symbol"}],"note":"Exact gene-symbol matches to the 122. Membership records the program evaluated in cancer cells; gene-level measurements and effect sizes need separate extraction. MBD3L2 is not substituted for MBD3L2B, and H3Y is not mapped to H3Y1 in this count.","interpretation":"Add as an early-embryo program evaluated in cancer, with the original gene-set source retained.","matched_proteins":9,"gene_set_source":{"citation":"Taubenschmid-Stowers et al., 2022","title":"8C-like cells capture the human zygotic genome activation program in vitro","url":"https://pubmed.ncbi.nlm.nih.gov/35216671/"}}]}