{"version":"2026-11-06.1","categories":[{"id":"early_embryo","label":"Early embryo","definition":"Human preimplantation embryo RNA or published embryo gene-activation evidence."},{"id":"oocyte_maternal","label":"Oocyte / maternal","definition":"Oocyte RNA, oocyte protein, or published maternal-effect function; species is recorded for each finding."},{"id":"reproductive_secretion","label":"Reproductive secretion","definition":"Reproductive-tract secretions or sperm-associated proteins identified in the focused publication review. Four proteins are currently annotated; a systematic secretion-catalog review is pending."},{"id":"testis","label":"Testis / male germ cells","definition":"RNA in testis tissue or cells, including male germ cells."},{"id":"placenta","label":"Placenta / trophoblast","definition":"RNA in placental tissue or cells, including trophoblast populations."},{"id":"gastrulation","label":"Gastrulation","definition":"RNA in the human Carnegie-stage-7 embryo dataset."},{"id":"other_reproductive","label":"Other reproductive","definition":"Released reproductive association without one of the more specific reproductive tags above."},{"id":"other_developmental","label":"Other developmental","definition":"Released developmental association without a stage-specific tag in this annotation."},{"id":"uncategorized","label":"Not categorized","definition":"No biological category has been assigned in this annotation."}],"rules":{"rna_minimum":5,"rna_units":["TPM","nTPM"],"normal_context_input":"All supported testis, placenta and oocyte contexts from the pinned normal-expression replay, before the display top-five limit","developmental_support":"At least 20 cells, 5 positive cells and 10% positive at 1 TPM; lineage mean at least 5 TPM","assignment":"Multiple tags per protein; evidence records retain the study, stage, compartment and measured value. Biological tags do not change CTA admission."},"curated_assignments":[{"gene_ids":["ENSG00000213921"],"label":"LEUTX","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5087614/","source_title":"The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation","model":"Human embryos and human embryonic stem-cell overexpression","basis":"LEUTX and DPRX regulate an early-embryo transcriptional program. The paper also examines cancer-cell-line expression."},{"gene_ids":["ENSG00000204595"],"label":"DPRX","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5087614/","source_title":"The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation","model":"Human embryos and human embryonic stem-cell overexpression","basis":"LEUTX and DPRX regulate an early-embryo transcriptional program. The paper also examines cancer-cell-line expression."},{"gene_ids":["ENSG00000204595"],"label":"DPRX","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4944136/","source_title":"Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos","model":"Human embryo transcripts and human stem-cell functional assays","basis":"DPRX, DUXA, DUXB and TPRX2 are included in a study of human preimplantation homeobox factors."},{"gene_ids":["ENSG00000258873"],"label":"DUXA","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4944136/","source_title":"Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos","model":"Human embryo transcripts and human stem-cell functional assays","basis":"DPRX, DUXA, DUXB and TPRX2 are included in a study of human preimplantation homeobox factors."},{"gene_ids":["ENSG00000282757"],"label":"DUXB","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4944136/","source_title":"Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos","model":"Human embryo transcripts and human stem-cell functional assays","basis":"DPRX, DUXA, DUXB and TPRX2 are included in a study of human preimplantation homeobox factors."},{"gene_ids":["ENSG00000259009"],"label":"TPRX2","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4944136/","source_title":"Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos","model":"Human embryo transcripts and human stem-cell functional assays","basis":"DPRX, DUXA, DUXB and TPRX2 are included in a study of human preimplantation homeobox factors."},{"gene_ids":["ENSG00000213921"],"label":"LEUTX","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9978639/","source_title":"Comprehensive characterization of the embryonic factor LEUTX","model":"Human cell models, proteomics and transcriptional assays","basis":"LEUTX regulates ZNF280A and TPRX2. The study reports TPRX2 transcription and function despite its historical pseudogene annotation."},{"gene_ids":["ENSG00000169548"],"label":"ZNF280A","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9978639/","source_title":"Comprehensive characterization of the embryonic factor LEUTX","model":"Human cell models, proteomics and transcriptional assays","basis":"LEUTX regulates ZNF280A and TPRX2. The study reports TPRX2 transcription and function despite its historical pseudogene annotation."},{"gene_ids":["ENSG00000259009"],"label":"TPRX2","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9978639/","source_title":"Comprehensive characterization of the embryonic factor LEUTX","model":"Human cell models, proteomics and transcriptional assays","basis":"LEUTX regulates ZNF280A and TPRX2. The study reports TPRX2 transcription and function despite its historical pseudogene annotation."},{"gene_ids":["ENSG00000282757"],"label":"DUXB","category_id":"early_embryo","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9978639/","source_title":"Comprehensive characterization of the embryonic factor LEUTX","model":"Human cell models, proteomics and transcriptional assays","basis":"LEUTX regulates ZNF280A and TPRX2. The study reports TPRX2 transcription and function despite its historical pseudogene annotation."},{"gene_ids":["ENSG00000214102"],"label":"WEE2","category_id":"oocyte_maternal","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5985286/","source_title":"Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility","model":"Human genetics, affected oocytes and rescue experiments","basis":"WEE2 mutations caused fertilization failure in human oocytes. The study measured WEE2 protein and tested experimental rescue."},{"gene_ids":["ENSG00000203908"],"label":"KHDC3L","category_id":"oocyte_maternal","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4974340/","source_title":"Identification of Maturation-Specific Proteins by Single-Cell Proteomics of Human Oocytes","model":"Human oocyte proteomics","basis":"KHDC3L/ECAT1 was identified by proteomics in human oocytes."},{"gene_ids":["ENSG00000158077"],"label":"NLRP14","category_id":"oocyte_maternal","source_url":"https://www.sciencedirect.com/science/article/pii/S2211124723015437","source_title":"NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance","model":"Human infertility investigation and mechanistic experiments","basis":"NLRP14 deficiency was associated with female infertility, oocyte maturation defects and early embryonic arrest."},{"gene_ids":["ENSG00000205022"],"label":"PABPN1L","category_id":"oocyte_maternal","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7403729/","source_title":"PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition","model":"Mouse oocytes and embryos","basis":"Pabpn1l knockout disrupted the maternal-to-zygotic transition and early embryonic development in mice."},{"gene_ids":["ENSG00000171053"],"label":"PATE1","category_id":"reproductive_secretion","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/pmid/25760095/","source_title":"In-depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa","model":"Human reproductive tissues and proteins","basis":"Human reproductive-tissue proteomics identified epididymal enrichment of PATE1 and WFDC8."},{"gene_ids":["ENSG00000158901"],"label":"WFDC8","category_id":"reproductive_secretion","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/pmid/25760095/","source_title":"In-depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa","model":"Human reproductive tissues and proteins","basis":"Human reproductive-tissue proteomics identified epididymal enrichment of PATE1 and WFDC8."},{"gene_ids":["ENSG00000188655"],"label":"RNASE9","category_id":"reproductive_secretion","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2669477/","source_title":"Cloning, expression and location of RNase9 in human epididymis","model":"Human tissue RNA and immunolocalization","basis":"RNASE9 was cloned and localized in human epididymis; the study also reported sperm-associated protein."},{"gene_ids":["ENSG00000124157"],"label":"SEMG2","category_id":"reproductive_secretion","source_url":"https://pubmed.ncbi.nlm.nih.gov/12200457/","source_title":"Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues","model":"Human tissue RT-PCR and immunohistochemistry","basis":"Semenogelin II is a seminal-plasma protein."}],"counts":[{"id":"early_embryo","label":"Early embryo","definition":"Human preimplantation embryo RNA or published embryo gene-activation evidence.","all":184,"registered":125,"unlisted":59},{"id":"oocyte_maternal","label":"Oocyte / maternal","definition":"Oocyte RNA, oocyte protein, or published maternal-effect function; species is recorded for each finding.","all":37,"registered":27,"unlisted":10},{"id":"reproductive_secretion","label":"Reproductive secretion","definition":"Reproductive-tract secretions or sperm-associated proteins identified in the focused publication review. Four proteins are currently annotated; a systematic secretion-catalog review is pending.","all":4,"registered":0,"unlisted":4},{"id":"testis","label":"Testis / male germ cells","definition":"RNA in testis tissue or cells, including male germ cells.","all":435,"registered":404,"unlisted":31},{"id":"placenta","label":"Placenta / trophoblast","definition":"RNA in placental tissue or cells, including trophoblast populations.","all":25,"registered":17,"unlisted":8},{"id":"gastrulation","label":"Gastrulation","definition":"RNA in the human Carnegie-stage-7 embryo dataset.","all":26,"registered":7,"unlisted":19},{"id":"other_reproductive","label":"Other reproductive","definition":"Released reproductive association without one of the more specific reproductive tags above.","all":49,"registered":34,"unlisted":15},{"id":"other_developmental","label":"Other developmental","definition":"Released developmental association without a stage-specific tag in this annotation.","all":3,"registered":3,"unlisted":0},{"id":"uncategorized","label":"Not categorized","definition":"No biological category has been assigned in this annotation.","all":0,"registered":0,"unlisted":0}]}