{
  "taxon_id": 9606,
  "species": "human",
  "selection_status": "available",
  "evidence_status": "partial",
  "policy_id": "oncoref.cta-selection.2026-11-08.1",
  "universe": "19893 classified protein-equivalence groups from 19893 input groups",
  "universe_counts": {
    "counting_unit": "selected_reference_protein_equivalence_group",
    "input_groups": 19893,
    "classified_groups": 19893,
    "out_of_universe_groups": 0,
    "input_gene_loci": 20099,
    "classified_gene_loci": 20099,
    "out_of_universe_gene_loci": 0,
    "gene_count_note": "Gene sets can overlap; only disjoint protein-group counts add",
    "translation_support_eligible_groups": 19598,
    "translation_support_insufficient_groups": 295,
    "scope_note": "Every candidate record enters classification; translation support is a CTA admission requirement, not an inventory exclusion."
  },
  "reference": {
    "annotation_release": "115",
    "annotation_source": "Ensembl",
    "assembly_accession": "GCA_000001405.29",
    "content_provenance": {
      "gtf": "02df5a2a8c7a41e513209e0780c56cf197941b6b35ef8bab3e9a6317eecd17ef",
      "ncrna": "7825db09257902df82172928537c1da16cfe79edcca56425556f74f1507437a0",
      "protein": "7991ab37d09986eefdb5c77032b15370ab0e99918b78f235f3230c0302851c96",
      "rna": "93af088ed22a46daa9645fc6292fb120c1e4ffe791d24abbcbd35062666c03f1"
    },
    "identifier_namespaces": {
      "gene": "Ensembl gene",
      "protein": "Ensembl protein",
      "transcript": "Ensembl transcript"
    },
    "reference_id": "openvax:reference:v1:sha256:ba6f6186a301a3ef9217ea0199ec3b851f9da2eb43558b7ba7e0d6fcd9cd85e9",
    "schema": "openvax.reference",
    "schema_version": 1,
    "source_version": "Ensembl-115",
    "taxon_id": 9606
  },
  "limitations": [
    "Research prioritization calibrated using PRAME; no clinical safety or pediatric validation",
    "Developmental coverage is stage-limited; gastrulation and preimplantation measurements do not cover later fetal/postnatal development",
    "Native RNA units remain separate and nominal thresholds lack assay-specific toxicity calibration",
    "Low normal protein is a tolerated flag; author descriptions and HPA categories retain different scales",
    "Representative-protein equivalence is not exhaustive isoform identity",
    "Reviewed TCR-T experience supplies at most one RNA ladder step; tested peptide/HLA/product limits apply and clinical or protein exclusions remain independent",
    "HPA diffuseness applies only to complete adult/placental profiles; developmental concentration is unassessed without a comparable panel",
    "Other includes assessed noncandidates and held/incomplete cases. Subtype does not establish evidence completeness or sequence allowance.",
    "Rare-cell screening uses the existing brain, spinal-cord, heart and selected lung CELLxGENE panels. At least 1% detection in a Vital population supplies exclusion evidence; Protected detection supplies a review hold. Detection frequency is not abundance. Unmeasured ages, organs and excluded lineages remain coverage limits, not allowances.",
    "Indirect reproductive-cell association can reflect passenger or ambient RNA; it establishes sample-site association, not the producing cell. All normal and concentration gates still apply."
  ],
  "entities": 19893,
  "counts": {
    "CTA": 607,
    "Unsafe": 18259,
    "Other": 1027,
    "Unassigned": 0
  },
  "other_subtypes": {
    "Nonreproductive": 573,
    "Translation": 380,
    "Nested": 28,
    "Held": 27,
    "Contained": 15,
    "Diffuse": 4
  },
  "evidence_categories": {
    "nomination": {
      "used_sources": 0,
      "available_sources": 22,
      "identified_sources": 22
    },
    "reproductive_expression": {
      "used_sources": 5,
      "available_sources": 5,
      "identified_sources": 5
    },
    "developmental_expression": {
      "used_sources": 2,
      "available_sources": 2,
      "identified_sources": 2
    },
    "tumor_expression": {
      "used_sources": 2,
      "available_sources": 2,
      "identified_sources": 2
    },
    "normal_bulk_rna": {
      "used_sources": 3,
      "available_sources": 3,
      "identified_sources": 3
    },
    "normal_cell_rna": {
      "used_sources": 7,
      "available_sources": 7,
      "identified_sources": 7
    },
    "immune_rna": {
      "used_sources": 3,
      "available_sources": 3,
      "identified_sources": 3
    },
    "normal_protein": {
      "used_sources": 4,
      "available_sources": 4,
      "identified_sources": 4
    },
    "clinical_safety": {
      "used_sources": 14,
      "available_sources": 14,
      "identified_sources": 14
    },
    "translation_evidence": {
      "used_sources": 2,
      "available_sources": 2,
      "identified_sources": 2
    }
  }
}