{
  "schema": "oncoref.cta-decision-contract",
  "schema_version": 1,
  "contract_id": "oncoref.cta-decision-contract.2026-11-05.1",
  "role_policy_id": "oncoref.sequence-roles.2026-11-04.1",
  "title": "CTA and oncofetal candidate selection",
  "definition": "An OncoRef CTA candidate is a reference-resolved protein with supported cancer expression and qualifying reproductive or developmental association that passes the named normal-tissue evidence, coverage and selection rules. CTA admission requires qualifying coding annotation or supported ncORF evidence and a complete, approved MANE Select or Ensembl canonical representative, with any conflicting coding evidence resolved. Every input record is assessed, including those with insufficient translation support.",
  "categories": {
    "CTA": "Candidate under the named policy; not presentation or clinical clearance",
    "Unsafe": "Normal-tissue or applicable clinical evidence establishes policy exclusion",
    "Other": "Not admitted; inspect every reason and assessment status"
  },
  "assessment_states": {
    "screened": "Declared assessment completed; not exhaustive biological coverage",
    "incomplete_evidence": "Required coverage or evidence resolution is incomplete",
    "normal_evidence_hold": "Normal evidence requires review without establishing exclusion",
    "translation_review": "Incomplete annotation, uncertain translation or unresolved representative-protein evidence",
    "unassessed": "No applicable selection policy or no completed assessment"
  },
  "interpretation_states": {
    "accepted": "The specified observation is supported within its recorded scope",
    "unresolved": "A material identity, assay, context or interpretation question remains",
    "rejected": "The claimed observation is not supported; retain the rationale and source"
  },
  "interpretation_note": "Review completion, interpretation and policy effect are separate. A completed review may retain unresolved evidence; a rejected claim is not proof of absence.",
  "support_routes": [
    "testicular",
    "other_reproductive",
    "placental",
    "embryonic_fetal"
  ],
  "support_route_note": "Routes may overlap; a developmental route is not adult testis restriction",
  "sequence_roles": {
    "exclude": "Retain applicable exclusion evidence; it takes precedence across occurrences",
    "review": "Evidence, identity, coverage or sequence qualification needs resolution",
    "allow": "No exclusion from this assessed record under the named policy"
  },
  "role_precedence": [
    "exclude",
    "review",
    "allow"
  ],
  "role_scope": "selected_representative_protein",
  "translation_scope": "This decision interface does not qualify every translation or isoform",
  "consumer_scope": "Use explicitly qualified records as a reference for exact subtraction or approximate near-self screening. Preserve every source occurrence and coverage gap. Patient-HLA prediction, similarity cutoffs and intervention rules are downstream policy; exact matching does not validate approximate matching.",
  "prohibited_shortcuts": [
    "Blanket exemption of historical CTA nominations from normal-reference evidence",
    "A second legacy IHC filter that silently drops exclusions from other evidence",
    "Interpreting Other, absent records or unmeasured panels as negative normal evidence",
    "Transfer of human numerical rules to another species by symbol or orthology"
  ],
  "taxon_id": 9606,
  "species": "human",
  "selection_policy_id": "oncoref.cta-selection.2026-11-08.1",
  "selection_status": "available",
  "reference_id": "openvax:reference:v1:sha256:ba6f6186a301a3ef9217ea0199ec3b851f9da2eb43558b7ba7e0d6fcd9cd85e9"
}