[ { "entity_id": "PEG:70f59520a0e26b23f88e", "protein": "LCN9", "gene_ids": [ "ENSG00000148386" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1016/j.gene.2004.06.027", "10.1111/andr.13350", "10.1371/journal.pone.0254802" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000148386" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000148386": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Reproductive secretory families", "biology_categories": [ "other_reproductive" ], "evidence_summary": "LCN9 belongs to the epididymal lipocalin literature. Promoter-localization and knockout fertility experiments retrieved here are mouse studies; they support the biological category without establishing human tumor protein.", "judgment": "Mouse reproductive studies support the category; human tumor secretion is unverified.", "tumor_max_tpm": 85.4901, "tumor_max_ptpm": 110.061, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.0019506934, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:6c783a0d5f840cd1c046", "protein": "TEDDM1", "gene_ids": [ "ENSG00000203730" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1095/biolreprod.105.048058" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000203730" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000203730": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Other poorly characterized reproductive proteins", "biology_categories": [ "other_reproductive" ], "evidence_summary": "The retrieved discovery work concerns mouse epididymis-specific transcripts. This supports a reproductive-family lead, while exact human TEDDM1 protein and tumor restriction remain unverified.", "judgment": "Reproductive RNA is strong; the retrieved discovery experiment is mouse evidence, not human tumor protein evidence.", "tumor_max_tpm": 15.1771, "tumor_max_ptpm": 20.3653, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.1570119152, "reproductive_max_ntpm": 562.1 }, { "entity_id": "PEG:1a92fb62ff88120a4cea", "protein": "PABPN1L", "gene_ids": [ "ENSG00000205022" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "https://pmc.ncbi.nlm.nih.gov/articles/PMC7403729/" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000205022" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000205022": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Maternal / oocyte-associated proteins", "biology_categories": [ "early_embryo", "oocyte_maternal" ], "evidence_summary": "Pabpn1l knockout disrupted the maternal-to-zygotic transition and early embryonic development in mice.", "judgment": "Mouse experiments establish a maternal-to-zygotic transition role and human RNA supports the developmental association. Human protein and tumor evidence remain the next steps.", "tumor_max_tpm": 58.4644, "tumor_max_ptpm": 18.5333, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 373.8994407841, "reproductive_max_ntpm": 0.4 }, { "entity_id": "PEG:d36602dc99457334ed43", "protein": "DEFB113", "gene_ids": [ "ENSG00000214642" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1152/physiolgenomics.00104.2005", "10.3389/froh.2022.817249" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000214642" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000214642": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Reproductive secretory families", "biology_categories": [ "other_reproductive" ], "evidence_summary": "A cross-species defensin catalog contains the human family member. The gingival-expression paper is a non-human primate experiment; much of the reproductive-expression work in the catalog is rat. Neither establishes normal human gingival protein.", "judgment": "HPA tumor RNA reaches 63.7 pTPM despite a 2.3 TPM maximum in the separate tumor source. Human tumor secretion has not been established.", "tumor_max_tpm": 2.2679, "tumor_max_ptpm": 63.7402, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": null, "reproductive_max_ntpm": 46.1 }, { "entity_id": "PEG:ad22a7bf35b45ca0ec8a", "protein": "ENSG00000237378", "gene_ids": [ "ENSG00000237378" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000237378" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000237378": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "early_embryo", "gastrulation" ], "evidence_summary": "No exact-locus paper was found in the searched index. Retain the anonymous coding locus and its measured developmental expression; a stable name and sequence-linked literature mapping are still missing.", "judgment": "Establish a sequence-linked identity and endogenous protein detection before stronger claims.", "tumor_max_tpm": 8.1615011367, "tumor_max_ptpm": 10.5562, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 15.833605134, "reproductive_max_ntpm": 2.0 }, { "entity_id": "PEG:7a81a2cf3631c7adb27c", "protein": "ENSG00000241690", "gene_ids": [ "ENSG00000241690" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000241690" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000241690": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "testis" ], "evidence_summary": "Present in the broad expression-scoring table, but no gene-specific paper was verified. The selected coding sequence and expression measurements are the current support.", "judgment": "Coding annotation and expression support inclusion; the broad scoring table supplies no independent functional validation.", "tumor_max_tpm": 5.7012194598, "tumor_max_ptpm": 9.9904, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": null, "reproductive_max_ntpm": 13.5 }, { "entity_id": "PEG:5dca19749634c5267bc2", "protein": "H2AL1Q", "gene_ids": [ "ENSG00000249467" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1186/s13072-017-0172-y", "10.1186/s13072-022-00467-2" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000249467" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000249467": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Germ-cell structure and chromatin", "biology_categories": [ "testis" ], "evidence_summary": "The targeted H2A.L.1 proteomics paper studies mouse testis, not the human H2AL1Q locus. Histone nomenclature provides an identity reference but not human protein detection.", "judgment": "The retrieved proteomics is mouse evidence; human copy-specific protein detection is missing.", "tumor_max_tpm": 4.0237682387, "tumor_max_ptpm": null, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.0166299904, "reproductive_max_ntpm": 7.7 }, { "entity_id": "PEG:bb4b19645fd0c3e6333b", "protein": "TAF11L14", "gene_ids": [ "ENSG00000250782" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1186/1471-2164-11-632" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000250782" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000250782": [] }, "released_classification": "CTA", "pending_classification": "Other:Review", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "The same macrosatellite study supports family transcription in reproductive and neural tissues. No TAF11L14-specific protein result was verified; normal evidence remains unresolved at the individual copy.", "judgment": "Other:Review in the pending replay. The same unresolved neural/reproductive macrosatellite signal applies; a separate copy-specific assay is needed. The published label remains CTA until release.", "tumor_max_tpm": 38.6611, "tumor_max_ptpm": 27.9342, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 7.8309512655, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:39099f3e417798616cca", "protein": "PTTG1IP2", "gene_ids": [ "ENSG00000251154" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000251154" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000251154": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Other poorly characterized reproductive proteins", "biology_categories": [ "testis" ], "evidence_summary": "No dedicated study of PTTG1IP2 was verified. Extracellular-vesicle work on PTTG1IP concerns the parent gene and does not validate this paralog.", "judgment": "Little characterization and about 3.2 TPM maximum tumor RNA. PTTG1IP/PBF experiments do not establish this paralog's function.", "tumor_max_tpm": 3.2257464967, "tumor_max_ptpm": 1.9395, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.1852074158, "reproductive_max_ntpm": 9.3 }, { "entity_id": "PEG:49474c33cb94125c2178", "protein": "UBTFL1", "gene_ids": [ "ENSG00000255009" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1093/hmg/ddp512", "10.1093/molehr/gaab012" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000255009" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000255009": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "The Hmgpi discovery paper demonstrates preimplantation function in mouse and identifies three predicted human homologs, UBTFL1-3. That is a family/orthology link, not direct functional validation of human UBTFL1.", "judgment": "The claimed human Ubtfl1 qPCR assay in Zhu 2021 uses primers matching mouse Sod1; do not credit that assay. UniProt has protein-level evidence, but this review did not resolve tissue-specific peptides.", "tumor_max_tpm": 26.9973358169, "tumor_max_ptpm": 7.7643, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 47.1893328066, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:a90c8529360aad1a85c2", "protein": "OOSP4B", "gene_ids": [ "ENSG00000255393" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000255393" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000255393": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Maternal / oocyte-associated proteins", "biology_categories": [ "early_embryo", "oocyte_maternal" ], "evidence_summary": "No verified study of the exact human OOSP4B protein was found. The name suggests a reproductive family, but the retained oocyte category comes from measured RNA, not a borrowed OOSP-family function.", "judgment": "Its category comes from measured RNA; OOSP1 or OOSP4A experiments do not validate OOSP4B.", "tumor_max_tpm": 30.6163, "tumor_max_ptpm": 1.1848, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 52.974036444, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:24c69136cf11d62d3f1a", "protein": "ENSG00000258417", "gene_ids": [ "ENSG00000258417" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000258417" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000258417": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "early_embryo" ], "evidence_summary": "Present in the broad expression-scoring table without a verified dedicated study. Resolve sequence/transcript identity before transferring any named-gene publication.", "judgment": "Resolve transcript and sequence identity before importing named-gene literature.", "tumor_max_tpm": 6.7560681401, "tumor_max_ptpm": 98.6164, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 6.6366257103, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:cef2f2b2102163b3f577", "protein": "GOLGA8T", "gene_ids": [ "ENSG00000261247" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000261247" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000261247": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Other poorly characterized reproductive proteins", "biology_categories": [ "testis" ], "evidence_summary": "No dedicated expression, function or antigen paper was verified. Genome-duplication annotation and the released RNA observations remain the evidence base.", "judgment": "Family homology does not establish this copy's protein production.", "tumor_max_tpm": 13.739955083, "tumor_max_ptpm": 1.3856, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.7937234738, "reproductive_max_ntpm": 6.7 }, { "entity_id": "PEG:4ec273108e0908d9e2f3", "protein": "ATF7-NPFF", "gene_ids": [ "ENSG00000267281" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000267281" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000267281": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "gastrulation" ], "evidence_summary": "No dedicated study of the exact readthrough protein was verified. Expression-table search leads do not establish the fusion transcript, translated junction or protein.", "judgment": "The coding reference passes; tumor RNA does not establish the readthrough junction or the exact protein. Junction and protein identity are the priority.", "tumor_max_tpm": 79.6491184636, "tumor_max_ptpm": 20.0396, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 5.1198668119, "reproductive_max_ntpm": 0.2 }, { "entity_id": "PEG:a8f90dfeb55ae984bf17", "protein": "CTAGE15", "gene_ids": [ "ENSG00000271079" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000271079" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000271079": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Other poorly characterized reproductive proteins", "biology_categories": [ "testis" ], "evidence_summary": "No gene-specific functional or antigen study was verified. The cTAGE family name and broad transcriptomic search hits do not establish that this member is a cancer-testis antigen.", "judgment": "Its cTAGE-family name is not antigen evidence. Verify this copy rather than borrowing other CTAGE results.", "tumor_max_tpm": 31.0523532805, "tumor_max_ptpm": 1.9817, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.0176977199, "reproductive_max_ntpm": 7.8 }, { "entity_id": "PEG:1f1a10caec58d2d32020", "protein": "ENSG00000273155", "gene_ids": [ "ENSG00000273155" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000273155" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000273155": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "early_embryo", "gastrulation" ], "evidence_summary": "UniProt Q8TCC3 links this locus together with two other loci to mitochondrial ribosomal protein uL30m. That shared annotation cannot assign mitochondrial protein experiments to this selected locus or sequence.", "judgment": "Prioritize identity review. A shared mitochondrial ribosomal-protein annotation makes it essential to distinguish this locus from MRPL30-associated records before transferring normal or tumor protein evidence.", "tumor_max_tpm": 50.9227837603, "tumor_max_ptpm": 43.277, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 23.0908323586, "reproductive_max_ntpm": 0.6 }, { "entity_id": "PEG:cd8eaef0aa7ffbe4d21b", "protein": "ENSG00000274944", "gene_ids": [ "ENSG00000274944" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000274944" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000274944": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "early_embryo" ], "evidence_summary": "No verified exact-locus study. Complete 110-aa Ensembl canonical translation; TSL 2; developmental and tumor RNA.", "judgment": "The 110-aa canonical protein passes, with TSL 2 and no MANE designation. No exact-locus study was verified; database links to MYCBP are not evidence for this protein.", "tumor_max_tpm": 13.5360479633, "tumor_max_ptpm": 82.1963, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 52.1614695681, "reproductive_max_ntpm": 4.9 }, { "entity_id": "PEG:09ae2908a32167d7f9c6", "protein": "PRAMEF18", "gene_ids": [ "ENSG00000279804" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1038/s41598-019-46981-4" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000279804" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000279804": [] }, "released_classification": "CTA", "pending_classification": "Other:Review", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "A human pulmonary-arterial smooth-muscle microarray/network study lists a combined PRAMEF18/PRAMEF19 signal after cocaine/HIV-Tat exposure. It does not resolve PRAMEF18 alone or demonstrate protein.", "judgment": "Other:Review in the pending replay. A treated human vascular-cell study reports a combined PRAMEF18/PRAMEF19 feature; the responsible copy is unresolved. The published label remains CTA until release.", "tumor_max_tpm": 3.580192849, "tumor_max_ptpm": 10.4237, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 137.5010848217, "reproductive_max_ntpm": 0.1 }, { "entity_id": "PEG:7bad8fb4daf83a0e99c7", "protein": "CTXND2", "gene_ids": [ "ENSG00000283324" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000283324" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000283324": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Other poorly characterized reproductive proteins", "biology_categories": [ "placenta" ], "evidence_summary": "The review found annotation and nonspecific search leads, but no verified study of CTXND2 protein or function. Its current support remains the coding reference and measured expression datasets.", "judgment": "Placental association and the coding reference are the support; function and protein localization are uncharacterized.", "tumor_max_tpm": 16.246, "tumor_max_ptpm": 29.0378, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 0.1824754186, "reproductive_max_ntpm": 0.4 }, { "entity_id": "PEG:642d515a9a34d19423e5", "protein": "TAF11L11", "gene_ids": [ "ENSG00000283740" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1186/1471-2164-11-632" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000283740" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000283740": [] }, "released_classification": "CTA", "pending_classification": "Other:Review", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "The TAF11-like macrosatellite study detects family-level RNA in testis, fetal brain and whole brain. It does not resolve TAF11L11 individually. Keep the normal-brain signal as an unresolved family/identity finding.", "judgment": "Other:Review in the pending replay. The macrosatellite study reports family RNA in brain and testis without resolving this copy. The published label remains CTA until release.", "tumor_max_tpm": 35.5198, "tumor_max_ptpm": 110.972, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 158.524983005, "reproductive_max_ntpm": 0.2 }, { "entity_id": "PEG:67dec9123a9456d1115e", "protein": "TAF11L13", "gene_ids": [ "ENSG00000283776" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1186/1471-2164-11-632" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000283776" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000283776": [] }, "released_classification": "CTA", "pending_classification": "Other:Review", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "Annotation-linked TAF11-like macrosatellite RNA is reported in testis and brain, including whole brain. The source lacks a TAF11L13-specific assay, so it creates a copy-resolution question rather than a proven member-specific exclusion.", "judgment": "Other:Review in the pending replay. Family-level brain RNA cannot be assigned to, or dismissed for, this copy. The published label remains CTA until release.", "tumor_max_tpm": 23.501952716, "tumor_max_ptpm": 11.9038, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 11.1521473265, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:b6708d76c220960f3383", "protein": "SSU72L4", "gene_ids": [ "ENSG00000283873" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000283873" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000283873": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "No exact SSU72L4 study was verified. Search-engine leads for other CTD phosphatases were not accepted as evidence for this locus.", "judgment": "Substantial tumor RNA warrants follow-up; family-wide phosphatase literature is not exact-copy protein evidence.", "tumor_max_tpm": 343.5100000008, "tumor_max_ptpm": 14.6817, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 260.2370523191, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:77d4ac745a2951e13e16", "protein": "SSU72L5", "gene_ids": [ "ENSG00000284018" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000284018" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000284018": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "No exact SSU72L5 study was verified. A yeast CTD-phosphatase search hit is unrelated to this human locus.", "judgment": "Substantial tumor RNA warrants follow-up; endogenous protein production and exact-copy attribution remain unverified.", "tumor_max_tpm": 413.8800000004, "tumor_max_ptpm": 9.9388, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 218.6558478278, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:28a89961ee80474f1996", "protein": "SSU72L2", "gene_ids": [ "ENSG00000284306" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000284306" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000284306": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "No exact SSU72L2 protein study was verified. Nomenclature-resource coverage documents the name, not a functional or expression experiment.", "judgment": "It has the highest recorded tumor TPM maximum in this gap set, but neither enzyme function nor endogenous protein follows from that RNA value.", "tumor_max_tpm": 990.9100000014, "tumor_max_ptpm": 29.3149, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 318.6106037429, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:276090530a257361d2f0", "protein": "SSU72L3", "gene_ids": [ "ENSG00000284546" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000284546" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000284546": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo" ], "evidence_summary": "Exact-symbol, historical-alias and locus searches returned no verified gene-specific study. Its evidence remains reference annotation and the released embryo-associated RNA.", "judgment": "Its RNA pattern is promising; resolve this copy independently of SSU72 and the other SSU72L loci.", "tumor_max_tpm": 362.7899999998, "tumor_max_ptpm": 16.9457, "reliable_tumor_protein": false, "replicated_tumor_rna": true, "developmental_lineage_max_tpm": 145.8824778264, "reproductive_max_ntpm": 0.0 }, { "entity_id": "PEG:672e705b44fa7730dc51", "protein": "ENSG00000284934", "gene_ids": [ "ENSG00000284934" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000284934" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000284934": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "early_embryo" ], "evidence_summary": "A broad monkeypox/HEK293T omics search lead was found, but no exact-locus protein finding was verified. Current evidence remains annotation and expression measurements.", "judgment": "Tumor RNA is substantial in at least one sample; exact-locus translation remains experimentally unverified.", "tumor_max_tpm": 77.0687604092, "tumor_max_ptpm": 28.9949, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 6.5781713732, "reproductive_max_ntpm": 0.5 }, { "entity_id": "PEG:b7668edb7de9a67040bb", "protein": "MSANTD5", "gene_ids": [ "ENSG00000285891" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000285891" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000285891": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Duplicated regulatory and antigen-related families", "biology_categories": [ "early_embryo", "testis" ], "evidence_summary": "No exact-symbol or locus paper was found in the searched index. Current RefSeq/Ensembl annotation establishes a coding record, while protein function and experimental tissue production remain unverified.", "judgment": "Tumor maxima are 3.4 TPM and 12.2 HPA pTPM in separate sources. Its high developmental RNA establishes the association, while protein function remains uncharacterized.", "tumor_max_tpm": 3.4303121766, "tumor_max_ptpm": 12.2279, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 848.6240078273, "reproductive_max_ntpm": 0.7 }, { "entity_id": "PEG:47ed981d53c2dfd72892", "protein": "SPADH", "gene_ids": [ "ENSG00000286135" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000286135" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000286135": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Reproductive secretory families", "biology_categories": [ "other_reproductive" ], "evidence_summary": "No specific human SPADH protein study was verified. Search hits chiefly concerned nonhuman spermadhesins or unrelated plant abbreviations. Human secretion cannot be inferred from the family name.", "judgment": "Human secretion and spermadhesin function need exact-sequence evidence; livestock spermadhesin studies do not establish them.", "tumor_max_tpm": 11.7358280001, "tumor_max_ptpm": 27.4119, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 4.3383706232, "reproductive_max_ntpm": 115.4 }, { "entity_id": "PEG:d576051097601567c804", "protein": "CIMIP3", "gene_ids": [ "ENSG00000287363" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [ "10.1038/s41467-026-69714-4" ], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000287363" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000287363": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Germ-cell structure and chromatin", "biology_categories": [ "testis" ], "evidence_summary": "A sperm doublet-microtubule structural study identifies CIMIP3 among shared microtubule-inner proteins in mouse sperm. It supplies a mechanistic lead, not direct human airway or tumor protein evidence.", "judgment": "Mouse sperm structure supports its biological category. Tumor maxima are 1.2 TPM and 55.4 HPA pTPM in separate sources, so the lower TPM value alone does not justify low priority.", "tumor_max_tpm": 1.201628737, "tumor_max_ptpm": 55.3853, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": 1.3795532356, "reproductive_max_ntpm": 36.8 }, { "entity_id": "PEG:27ae484f4ec3a7675ba0", "protein": "ENSG00000289809", "gene_ids": [ "ENSG00000289809" ], "nomination_sources": [], "exact_paper_sources": [], "related_sources": [], "covered_gene_ids": [], "uncovered_gene_ids": [ "ENSG00000289809" ], "paper_coverage": "no_paper", "per_gene_sources": { "ENSG00000289809": [] }, "released_classification": "CTA", "pending_classification": "CTA", "biological_group": "Unnamed loci and a readthrough", "biology_categories": [ "testis" ], "evidence_summary": "No exact-locus paper was found in the searched index. Its reference annotation and testis-associated RNA remain distinct from experimental translation or tumor-antigen evidence.", "judgment": "Lowest tumor-expression priority in this set: the recorded maximum is about 0.068 TPM. It passes the presence rule, but that is very weak evidence of a useful tumor target.", "tumor_max_tpm": 0.0678925289, "tumor_max_ptpm": null, "reliable_tumor_protein": false, "replicated_tumor_rna": false, "developmental_lineage_max_tpm": null, "reproductive_max_ntpm": 9.8 } ]