Ten CTA candidates: evidence and tumor prevalence

Release 1.35.0 still labels all ten CTA. The proposed curation places PRAMEF18 and TRIM75 on review hold. A dash means no eligible measurement, not zero. Cohort views overlap; do not add their denominators.

Full rationale and linked papers · Candidate CSV · SSU72L2 cohort CSV

Candidate measurements

Protein / sources Next decision Protein annotation HPA IHC HPA MS Measured samples ≥1 TPM ≥5 TPM ≥10 TPM Maximum TPM
PRAMEF18 · HPA · UniProt Other:Review 3: Inferred from homology Uncertain shared antibody Not available 14370 6 0 0 3.58
SSU72L1 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 14143 45 7 2 387.74
SSU72L2 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 14143 50 6 3 990.91
SSU72L3 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 14143 39 3 3 362.79
SSU72L4 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 14143 48 9 4 343.51
SSU72L5 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 14143 36 3 2 413.88
TEDDM1 · HPA · UniProt CTA 1: Evidence at protein level Not assayed Not available 14381 172 26 8 15.18
TMEM269 · HPA · UniProt CTA 3: Inferred from homology Not assayed Not available 2861 802 35 4 22.85
TRIM75 · HPA · UniProt Other:Review 1: Evidence at protein level Not assayed Not available 14149 55 4 1 10.26
UBTFL1 · HPA · UniProt CTA 1: Evidence at protein level Not assayed Not available 14381 22 2 1 27.00

SSU72L2 cohorts

Cancer type Code Source coverage Measured samples Excluded samples ≥1 TPM ≥2 TPM ≥5 TPM ≥10 TPM Maximum TPM
Adrenocortical Carcinoma ACC Gene measured 77 0 0.00 0.00 0.00 0.00 0.09
Acinic Cell Carcinoma ACINIC Gene measured 2 1 0.00 0.00 0.00 0.00 0.00
Adenoid Cystic Carcinoma ADCC Gene measured 57 0 1.00 0.00 0.00 0.00 1.25
Atypical Teratoid/Rhabdoid Tumor ATRT Gene measured 4 0 0.00 0.00 0.00 0.00 0.03
Basal Cell Carcinoma BCC Gene not measured 0 0 — — — — —
Burkitt Lymphoma BL Gene measured 182 2 5.00 2.00 0.00 0.00 2.68
Bladder Urothelial Carcinoma BLCA Gene measured 407 0 2.00 1.00 0.00 0.00 4.47
Breast Invasive Carcinoma BRCA Gene measured 1098 1 0.00 0.00 0.00 0.00 0.84
Basal-like BRCA_Basal Gene measured 172 0 0.00 0.00 0.00 0.00 0.33
HER2-enriched BRCA_HER2 Gene measured 77 0 0.00 0.00 0.00 0.00 0.84
Luminal A BRCA_LumA Gene measured 501 0 0.00 0.00 0.00 0.00 0.25
Luminal B BRCA_LumB Gene measured 199 0 0.00 0.00 0.00 0.00 0.14
Normal-like BRCA_Normal Gene measured 35 0 0.00 0.00 0.00 0.00 0.07
Triple-negative breast cancer BRCA_TNBC Gene measured 157 0 0.00 0.00 0.00 0.00 0.33
B-cell Acute Lymphoblastic Leukemia B_ALL Gene measured 153 1 0.00 0.00 0.00 0.00 0.48
Cervical Squamous / Adenocarcinoma CESC Gene measured 306 0 3.00 2.00 1.00 0.00 5.15
Cholangiocarcinoma CHOL Gene measured 36 0 0.00 0.00 0.00 0.00 0.61
Craniopharyngioma CRANIO Gene measured 29 0 0.00 0.00 0.00 0.00 0.37
Diffuse Midline Glioma H3 K27-altered DIPG Gene measured 32 0 0.00 0.00 0.00 0.00 0.01
Chronic Lymphocytic Leukemia CLL Gene measured 708 0 0.00 0.00 0.00 0.00 0.57
Chronic Myeloid Leukemia CML Gene not measured 0 0 — — — — —
Colon Adenocarcinoma COAD Gene measured 290 0 0.00 0.00 0.00 0.00 0.06
MSI-H Colon Adenocarcinoma COAD_MSI Gene measured 50 0 0.00 0.00 0.00 0.00 0.05
MSS Colon Adenocarcinoma COAD_MSS Gene measured 226 0 0.00 0.00 0.00 0.00 0.06
Cutaneous T-cell Lymphoma CTCL Gene not measured 0 0 — — — — —
Diffuse Large B-cell Lymphoma DLBC Gene measured 47 0 0.00 0.00 0.00 0.00 0.21
Esophageal Carcinoma ESCA Gene measured 182 0 0.00 0.00 0.00 0.00 0.21
Ependymoma EPN Gene not measured 0 0 — — — — —
Follicular Lymphoma FL Gene not measured 0 0 — — — — —
Gallbladder Carcinoma GBC Gene measured 10 0 0.00 0.00 0.00 0.00 0.00
Glioblastoma Multiforme GBM Gene measured 166 0 0.00 0.00 0.00 0.00 0.20
Hepatoblastoma HEPB Gene measured 20 0 0.00 0.00 0.00 0.00 0.00
Hodgkin Lymphoma HL Gene measured 3 2 0.00 0.00 0.00 0.00 0.00
Hairy Cell Leukemia HCL Gene not measured 0 0 — — — — —
Head and Neck Squamous Cell Carcinoma HNSC Gene measured 520 0 3.00 1.00 0.00 0.00 4.05
HPV- HNSC HNSC_HPVneg Gene measured 415 0 2.00 1.00 0.00 0.00 4.05
HPV+ HNSC HNSC_HPVpos Gene measured 72 0 1.00 0.00 0.00 0.00 1.43
Kidney Chromophobe KICH Gene measured 66 0 0.00 0.00 0.00 0.00 0.03
Kidney Renal Clear Cell KIRC Gene measured 531 0 0.00 0.00 0.00 0.00 0.19
Kidney Renal Papillary KIRP Gene measured 289 0 0.00 0.00 0.00 0.00 0.16
Acute Myeloid Leukemia LAML Gene measured 173 0 0.00 0.00 0.00 0.00 0.32
Acute Promyelocytic Leukemia LAML_APL Gene measured 19 1 0.00 0.00 0.00 0.00 0.12
AML ELN2017 Adverse LAML_ELNadv Gene measured 189 0 0.00 0.00 0.00 0.00 0.19
AML ELN2017 Favorable LAML_ELNfav Gene measured 238 0 0.00 0.00 0.00 0.00 0.21
AML ELN2017 Intermediate LAML_ELNint Gene measured 154 0 0.00 0.00 0.00 0.00 0.29
Lower Grade Glioma LGG Gene measured 522 1 0.00 0.00 0.00 0.00 0.16
Liver Hepatocellular Carcinoma LIHC Gene measured 368 0 0.00 0.00 0.00 0.00 0.54
Lung Adenocarcinoma LUAD Gene measured 515 0 0.00 0.00 0.00 0.00 0.51
EGFR-mutant LUAD LUAD_EGFR Gene measured 67 0 0.00 0.00 0.00 0.00 0.07
KRAS-mutant LUAD LUAD_KRAS Gene measured 153 0 0.00 0.00 0.00 0.00 0.33
STK11/KEAP1 LUAD LUAD_STK11 Gene measured 142 0 0.00 0.00 0.00 0.00 0.36
Lung Squamous Cell Carcinoma LUSC Gene measured 498 0 1.00 1.00 0.00 0.00 3.08
Medulloblastoma MBL Gene measured 125 0 3.00 3.00 0.00 0.00 4.15
Medulloblastoma Group 3 MBL_G3 Gene measured 44 0 1.00 1.00 0.00 0.00 3.95
Medulloblastoma Group 4 MBL_G4 Gene measured 39 0 2.00 2.00 0.00 0.00 4.15
Medulloblastoma SHH MBL_SHH Gene measured 25 0 0.00 0.00 0.00 0.00 0.05
Medulloblastoma WNT MBL_WNT Gene measured 17 0 0.00 0.00 0.00 0.00 0.08
Mantle Cell Lymphoma MCL Gene not measured 0 0 — — — — —
Myelodysplastic Syndrome MDS Gene measured 81 1 0.00 0.00 0.00 0.00 0.47
Meningioma MENINGIOMA Gene measured 379 5 7.00 2.00 0.00 0.00 4.72
Mesothelioma MESO Gene measured 87 0 0.00 0.00 0.00 0.00 0.43
Multiple Myeloma MM Gene measured 81 683 0.00 0.00 0.00 0.00 0.07
Myeloproliferative Neoplasms MPN Gene measured 45 0 0.00 0.00 0.00 0.00 0.55
Medullary Thyroid Carcinoma MTC Gene not measured 0 0 — — — — —
Neuroblastoma NBL Gene measured 155 0 0.00 0.00 0.00 0.00 0.36
Neuroblastoma MYCN-amplified NBL_MYCNamp Gene measured 33 0 0.00 0.00 0.00 0.00 0.24
Neuroblastoma MYCN-non-amplified NBL_MYCNnonamp Gene measured 122 0 0.00 0.00 0.00 0.00 0.36
Large-Cell Neuroendocrine Carcinoma Lung NEC_LUNG_LARGECELL Gene measured 69 0 2.00 1.00 1.00 0.00 8.42
Merkel Cell Carcinoma NEC_MERKEL Gene not measured 0 0 — — — — —
Lung Typical/Atypical Carcinoid NET_LUNG Gene measured 118 0 0.00 0.00 0.00 0.00 0.26
Midgut / Small Bowel Carcinoid NET_MIDGUT Gene measured 78 3 0.00 0.00 0.00 0.00 0.19
Pancreatic Neuroendocrine Tumor NET_PANCREAS Gene measured 30 3 0.00 0.00 0.00 0.00 0.14
Rectal Neuroendocrine Tumor NET_RECTAL Gene measured 18 0 0.00 0.00 0.00 0.00 0.23
Nasopharyngeal Carcinoma NPC Gene measured 4 0 0.00 0.00 0.00 0.00 0.00
NUT Carcinoma NUTM Gene not measured 0 0 — — — — —
Ovarian Serous Cystadenocarcinoma OV Gene measured 426 0 1.00 0.00 0.00 0.00 1.50
Pancreatic Adenocarcinoma PAAD Gene measured 178 1 0.00 0.00 0.00 0.00 0.06
Pheochromocytoma and Paraganglioma PCPG Gene measured 182 0 0.00 0.00 0.00 0.00 0.13
Prostate Adenocarcinoma PRAD Gene measured 496 0 0.00 0.00 0.00 0.00 0.97
Retinoblastoma RB Gene measured 15 0 0.00 0.00 0.00 0.00 0.14
Rectum Adenocarcinoma READ Gene measured 93 0 0.00 0.00 0.00 0.00 0.05
MSI-H Rectum Adenocarcinoma READ_MSI Gene measured 2 0 0.00 0.00 0.00 0.00 0.00
MSS Rectum Adenocarcinoma READ_MSS Gene measured 83 0 0.00 0.00 0.00 0.00 0.05
Rhabdoid Tumor RT Gene measured 63 0 1.00 0.00 0.00 0.00 1.01
Angiosarcoma SARC_ANGIO Gene measured 20 0 2.00 1.00 1.00 1.00 18.47
Alveolar Soft Part Sarcoma SARC_ASPS Gene measured 3 0 0.00 0.00 0.00 0.00 0.00
Clear Cell Sarcoma SARC_CCS Gene not measured 0 0 — — — — —
Chondrosarcoma SARC_CHON Gene measured 47 7 2.00 2.00 0.00 0.00 2.08
Chordoma SARC_CHOR Gene measured 20 0 0.00 0.00 0.00 0.00 0.00
Dedifferentiated Liposarcoma SARC_DDLPS Gene measured 48 0 1.00 0.00 0.00 0.00 1.62
Desmoplastic Small Round Cell Tumor SARC_DSRCT Gene measured 9 0 0.00 0.00 0.00 0.00 0.65
Epithelioid Hemangioendothelioma SARC_EHE Gene measured 1 0 0.00 0.00 0.00 0.00 0.00
Epithelioid Sarcoma SARC_EPITH Gene measured 5 0 0.00 0.00 0.00 0.00 0.07
High-grade Endometrial Stromal Sarcoma SARC_ESS_HG Gene not measured 0 0 — — — — —
Low-grade Endometrial Stromal Sarcoma SARC_ESS_LG Gene not measured 0 0 — — — — —
Ewing Sarcoma SARC_EWS Gene measured 101 0 0.00 0.00 0.00 0.00 0.14
Gastrointestinal Stromal Tumor SARC_GIST Gene measured 19 0 0.00 0.00 0.00 0.00 0.14
Infantile Fibrosarcoma SARC_IFS Gene measured 2 0 0.00 0.00 0.00 0.00 0.00
Congenital Mesoblastic Nephroma CMN Gene not measured 0 0 — — — — —
Inflammatory Myofibroblastic Tumor SARC_IMT Gene measured 4 0 0.00 0.00 0.00 0.00 0.05
Kaposi Sarcoma SARC_KS Gene measured 10 0 0.00 0.00 0.00 0.00 0.00
Low-grade Fibromyxoid Sarcoma SARC_LGFMS Gene measured 2 0 0.00 0.00 0.00 0.00 0.00
Leiomyosarcoma SARC_LMS Gene measured 151 0 0.00 0.00 0.00 0.00 0.70
Liposarcoma (Unspecified / Aggregate) SARC_LPS_UNSPEC Gene measured 92 0 1.00 0.00 0.00 0.00 1.62
Malignant Melanotic Nerve Sheath Tumor SARC_MMNST Gene measured 3 0 0.00 0.00 0.00 0.00 0.00
Malignant Peripheral Nerve Sheath Tumor SARC_MPNST Gene measured 13 0 0.00 0.00 0.00 0.00 0.04
Myxofibrosarcoma SARC_MYXFIB Gene measured 41 0 0.00 0.00 0.00 0.00 0.18
Myxoid Liposarcoma SARC_MYXLPS Gene not measured 0 0 — — — — —
Osteosarcoma SARC_OS Gene measured 262 0 1.00 0.00 0.00 0.00 1.17
PEComa (Perivascular Epithelioid Cell Tumor) SARC_PEC Gene not measured 0 0 — — — — —
Pleomorphic Liposarcoma SARC_PLEOLPS Gene not measured 0 0 — — — — —
Alveolar Rhabdomyosarcoma SARC_RMS_ARMS Gene measured 73 0 1.00 1.00 0.00 0.00 3.83
Embryonal Rhabdomyosarcoma SARC_RMS_ERMS Gene measured 95 0 2.00 2.00 1.00 1.00 990.91
Pleomorphic Rhabdomyosarcoma SARC_RMS_PRMS Gene measured 6 0 0.00 0.00 0.00 0.00 0.00
Spindle Cell / Sclerosing Rhabdomyosarcoma SARC_RMS_SSRMS Gene measured 8 0 0.00 0.00 0.00 0.00 0.11
Synovial Sarcoma SARC_SYN Gene measured 50 0 1.00 0.00 0.00 0.00 1.87
Undifferentiated Pleomorphic Sarcoma SARC_UPS Gene measured 110 0 0.00 0.00 0.00 0.00 0.53
Well-Differentiated Liposarcoma SARC_WDLPS Gene measured 5 0 0.00 0.00 0.00 0.00 0.00
Small Cell Lung Cancer SCLC Gene not measured 0 0 — — — — —
SCLC ASCL1-dominant SCLC_ASCL1 Gene not measured 0 0 — — — — —
SCLC NEUROD1-dominant SCLC_NEUROD1 Gene not measured 0 0 — — — — —
SCLC POU2F3-dominant SCLC_POU2F3 Gene not measured 0 0 — — — — —
SCLC YAP1-dominant SCLC_YAP1 Gene not measured 0 0 — — — — —
Skin Cutaneous Melanoma SKCM Gene measured 469 0 2.00 1.00 1.00 1.00 12.49
Stomach Adenocarcinoma STAD Gene measured 413 1 0.00 0.00 0.00 0.00 0.48
Chromosomal Instability Stomach Adenocarcinoma STAD_CIN Gene measured 221 0 0.00 0.00 0.00 0.00 0.48
EBV-positive Stomach Adenocarcinoma STAD_EBV Gene measured 30 0 0.00 0.00 0.00 0.00 0.18
Genomically Stable Stomach Adenocarcinoma STAD_GS Gene measured 50 0 0.00 0.00 0.00 0.00 0.33
MSI-H Stomach Adenocarcinoma STAD_MSI Gene measured 73 0 0.00 0.00 0.00 0.00 0.15
Testicular Germ Cell Tumors TGCT Gene measured 154 0 0.00 0.00 0.00 0.00 0.91
Thyroid Carcinoma THCA Gene measured 512 0 0.00 0.00 0.00 0.00 0.12
Thymoma THYM Gene measured 119 0 1.00 0.00 0.00 0.00 1.22
T-cell Acute Lymphoblastic Leukemia T_ALL Gene measured 264 0 1.00 1.00 0.00 0.00 3.59
Uterine Corpus Endometrial Carcinoma UCEC Gene measured 181 0 2.00 1.00 0.00 0.00 2.22
Endometrial Carcinoma Copy-Number-High (p53-abnormal) UCEC_CNH Gene measured 85 0 1.00 0.00 0.00 0.00 1.10
Endometrial Carcinoma Copy-Number-Low (NSMP) UCEC_CNL Gene measured 30 0 0.00 0.00 0.00 0.00 0.66
Endometrial Carcinoma MSI-H/MMRd UCEC_MSI Gene measured 41 0 1.00 1.00 0.00 0.00 2.22
Endometrial Carcinoma POLE-ultramutated UCEC_POLE Gene measured 16 0 0.00 0.00 0.00 0.00 0.18
Uterine Carcinosarcoma UCS Gene measured 57 0 1.00 0.00 0.00 0.00 1.17
Uveal Melanoma UVM Gene measured 79 0 0.00 0.00 0.00 0.00 0.07
Vulvar Squamous Cell Carcinoma VSCC Gene measured 9 0 0.00 0.00 0.00 0.00 0.06
Wilms Tumor / Nephroblastoma WILMS Gene measured 125 0 4.00 2.00 1.00 0.00 5.41
Cutaneous Squamous Cell Carcinoma cSCC Gene not measured 0 0 — — — — —