{
  "flow_id": "oncoref.cta-decision-flow.2026-11-08.1",
  "categories": [
    "CTA",
    "Other",
    "Unsafe"
  ],
  "other_subtypes": {
    "Review": "Required evidence is missing, conflicting, or blocks admission without establishing Unsafe.",
    "Expression": "Cancer presence, reproductive/developmental association or the applicable concentration rule fails.",
    "Sequence": "A nested protein lacks independent expression evidence, or at least 95% of its 9-mers occur in Unsafe proteins."
  },
  "steps": [
    {
      "order": 1,
      "question": "Normal or applicable clinical exclusion?",
      "if_yes": "Unsafe"
    },
    {
      "order": 2,
      "question": "Required evidence missing, conflicting or held?",
      "if_yes": "Other:Review"
    },
    {
      "order": 3,
      "question": "Nested or Unsafe-contained sequence?",
      "if_yes": "Other:Sequence"
    },
    {
      "order": 4,
      "question": "Cancer, reproductive/developmental or concentration requirement fails?",
      "if_yes": "Other:Expression"
    },
    {
      "order": 5,
      "question": "All applicable requirements pass",
      "if_yes": "CTA"
    }
  ],
  "translation_rule": "Qualifying coding reference or supported noncanonical ORF, plus a complete approved representative with conflicting coding evidence resolved. Experimental protein detection is not required for every annotated coding gene.",
  "annotations_not_categories": [
    "paper coverage",
    "experimental protein detection",
    "biological program",
    "tumor prevalence",
    "surface localization",
    "antigen presentation"
  ],
  "scope": "Genes in the assessed human inventory; no transfer of human evidence to another species."
}