Methods and full report · Download table
| Protein | Decision | Developmental TPM | Tumor maximum TPM | Normal evidence / review | Sources |
|---|---|---|---|---|---|
| CLDN25 | Other:Review | 0.1297 | 642.7 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Durante reports enriched adult human olfactory-cell RNA, supplying the existing hold. Claudin-family function does not establish the localization or indispensability of this exact protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. The 2024 variant study (with a 2026 correction) examines a patient and transfected HEK293/canine MDCKII/mouse endothelial models. It adds a barrier-function question, without establishing adult human neural protein or cytotoxic-injury causality. Reported enriched RNA in a defined adult human olfactory population. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record · CLDN25 variant and barrier-cell models (2024) · Correction to the CLDN25 variant study (2026) · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| IFNA4 | Unsafe | 0.02136 | 81.11 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Activated normal immune-cell protein supplies the existing Unsafe finding. Highly homologous interferons and a shared HPA reagent require assay-specific attribution. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Reported secreted normal immune-cell protein, increased after activation. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record · Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus |
| IFNW1 | Unsafe | 0.1449 | 24.08 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Activated normal immune-cell protein supplies the existing Unsafe finding. Resting bulk RNA misses induced production. Secretion does not identify every producing cell. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Reported secreted normal immune-cell protein, increased after activation. | HPA normal-tissue RNA, IHC and protein-evidence record · Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus |
| KRTAP21-1 | Other:Expression | 0.05235 | 17.2 | Admission reasons: Reproductive / embryonic association Hair-family membership identifies the compartment to examine but is not exact-protein proof. HPA lists MS protein-existence evidence without tissue or peptide attribution in its XML, whereas the retrieved UniProt entry remains homology-based. Zhang 2014 reports gene-specific qPCR in LoVo cancer cells; the paper's HCEC experiments are not a KRTAP21-1 normal-cell result. The current HPA response contains no tissue-IHC antibody assay for this protein. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record · Zhang 2014: parvovirus B19 and colorectal cancer cells · Litman and Stein 2023: KRTAP evolution and skin transcriptomics |
| MRGPRX4 | Unsafe | 0.03862 | 187 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Human dorsal-root-ganglion neuronal RNA and protein supply the existing Unsafe finding. The rare sensory-neuron compartment is absent from the ordinary bulk comparison. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Human normal DRG neurons show localized RNA and protein; approximately 6–8% of neurons are positive. | HPA normal-tissue RNA, IHC and protein-evidence record · MRGPRX4 is a bile acid receptor for human cholestatic itch |
| OC90 | Other:Review | 0.3192 | 142.8 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Inner-ear otoconial biology is strongly established in mice. The principal source cloned human PLA2L/OC90 but obtained native protein from mouse tissue; retain the human localization hold. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity | HPA normal-tissue RNA, IHC and protein-evidence record · Otoconin-90 cloning and mammalian otoconial matrix protein (1998) · Otoconin-90 — UniProtKB/Swiss-Prot 2026_03 |
| OR10A5 | Other:Review | 0.2802 | 120.5 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Durante Table 7 reports RNA in 1 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. Normal human olfactory-mucosa assay labeled OR10A5: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OR11H1 | Other:Review | 0.003374 | 43.63 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Zhao 2013 reports RNA in healthy-control PBMC and neurologically normal postmortem brain, with qPCR confirmation. This is normal non-olfactory RNA evidence; OR4M1 functional experiments do not establish OR11H1 protein or function. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Zhao 2013 reports RNA in healthy-control PBMC and neurologically normal postmortem brain, with qPCR confirmation. This is normal non-olfactory RNA evidence; OR4M1 functional experiments do not establish OR11H1 protein or function. | HPA normal-tissue RNA, IHC and protein-evidence record · Zhao 2013: PBMC and normal brain olfactory-receptor RNA |
| OR11H12 | Other:Review | 0.03796 | 56.55 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR11H2 | Other:Review | 0.03749 | 24.68 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR11H6 | Other:Review | 0.1343 | 35.54 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 22/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Durante Table 7 reports RNA in 1 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. Normal human olfactory-mucosa assay labeled OR11H6: 22/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OR12D2 | Other:Review | 0.0682 | 16.17 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 21/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR12D2: 21/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR13H1 | Other:Review | 0.06142 | 72.35 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 2/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR13H1: 2/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR1D5 | Other:Expression | 0.03838 | 55.5 | Admission reasons: Reproductive / embryonic association The Parkinson nasal-marker paper validates OR1D5 RNA in treated RPMI-2650 carcinoma cells. Its patient/control nasal-fluid validation concerns other genes; it does not establish normal OR1D5 production. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record · Nasal epithelial Parkinson markers: carcinoma model and clinical validation (2020) |
| OR1L1 | Other:Review | 0.3341 | 33.82 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR1L1: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR1L4 | Other:Review | 0.01303 | 125.2 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR1L4: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR1P1 | Other:Review | 0.04744 | 21.88 | Admission reasons: Reproductive / embryonic association | Translation qualification Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Translation review: the reference cannot supply a complete approved protein. Recorded failures: ambiguous_or_interrupted_sequence | designated_translation_incomplete | incomplete_stop | nonqualifying_transcript_biotype. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR2B2 | Other:Expression | 1.84 | 246.3 | Admission reasons: Reproductive / embryonic association The linked-receptor testicular-expression paper found in the search studies pigs. It cannot establish reproductive expression of human OR2B2. No exact-symbol assay occurs in the human olfactory qPCR table. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record · MHC-linked receptors and pig testis (2025; species mismatch) |
| OR2M2 | Other:Review | 0.1268 | 22.52 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 2 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Durante Table 7 reports RNA in 3 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. Normal human olfactory-mucosa assay labeled OR2M2: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Verbeurgt 2014: normal human olfactory-mucosa qPCR · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OR2M5 | Other:Review | 0.01047 | 40.95 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 3/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR2M5: 3/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR2S2 | Other:Review | 0.0296 | 14.71 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 23/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR2S2: 23/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR2T5 | Other:Expression | 0.08594 | 17.82 | Admission reasons: Reproductive / embryonic association Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR4D10 | Other:Review | 0.03373 | 193.8 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 1 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. Verbeurgt Table S3 reports 17/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Durante Table 7 reports RNA in 2 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. Normal human olfactory-mucosa assay labeled OR4D10: 17/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Verbeurgt 2014: normal human olfactory-mucosa qPCR · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OR4F21 | Other:Review | 0.1625 | 25.19 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR51B2 | Other:Review | 0.1003 | 26.48 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR51B2: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR51B6 | Other:Review | 0.5168 | 27.72 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge The human leukocyte study includes OR51B6 in an OR56B4/OR52A4/OR51B6 antibody mixture. The positive mixed stain leaves exact-receptor attribution unresolved and supplies a review hold rather than an exact-protein exclusion. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. The human leukocyte study includes OR51B6 in an OR56B4/OR52A4/OR51B6 antibody mixture. The positive mixed stain leaves exact-receptor attribution unresolved and supplies a review hold rather than an exact-protein exclusion. | HPA normal-tissue RNA, IHC and protein-evidence record · Class I odorant and taste receptors in circulating human leukocytes (2015) |
| OR52E5 | Other:Review | 0.4159 | 11.95 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 3 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Durante Table 7 reports RNA in 2 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OR52E6 | Other:Review | 0.9156 | 19.93 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 16/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. The authors cannot discriminate OR52E6 from OR52E8 with this assay. This is shared-assay evidence. Normal human olfactory-mucosa assay labeled OR52E6: 16/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR52E8 | Other:Review | 0.1598 | 21.69 | Admission reasons: Reproductive / embryonic association | Translation qualification | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 1 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. Verbeurgt Table S3 reports 17/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. The authors cannot discriminate OR52E8 from OR52E6 with this assay. This is shared-assay evidence. Normal human olfactory-mucosa assay labeled OR52E8: 17/26 donors at >=5 estimated RNA copies/20 ng. Translation review: the reference cannot supply a complete approved protein. Recorded failures: designated_translation_incomplete | incomplete_stop. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR56A5 | Other:Review | 0.07528 | 134 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 15/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR56A5: 15/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR5C1 | Other:Review | 0.009806 | 50.64 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR5C1: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR5D18 | Other:Review | 0.1123 | 40.97 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 0/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. The authors cannot discriminate OR5D18 from OR5D16 with this assay. This is shared-assay evidence. Braun 2007 reports OR73/OR5D18 in laser-microdissected normal human gut enterochromaffin cells; cultured-cell functional experiments are separate. OR73/OR5D18 RNA is reported in laser-microdissected human mucosal enterochromaffin cells. | HPA normal-tissue RNA, IHC and protein-evidence record · Braun 2007: human gut enterochromaffin-cell receptors · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR6S1 | Other:Review | 0.411 | 51.55 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 8/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Normal human olfactory-mucosa assay labeled OR6S1: 8/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR6V1 | Other:Review | 0.04206 | 63.79 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. Verbeurgt Table S3 reports 26/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. Multiple assays are retained individually. The gene-level donor count is their union, with each donor counted once. Normal human olfactory-mucosa assay labeled OR6V1: 26/26 donors at >=5 estimated RNA copies/20 ng. | HPA normal-tissue RNA, IHC and protein-evidence record · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR7G3 | Other:Expression | 0.007801 | 29.21 | Admission reasons: Reproductive / embryonic association A schizophrenia leukocyte RNA-seq study is an exact-symbol literature lead. A normal-control gene-specific result was not extracted, so this study supplies no normal-positive or normal-negative credit here. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record · Schizophrenia leukocyte RNA-seq (2020; discovery lead) |
| OR8S1 | Other:Expression | 0.1385 | 14.16 | Admission reasons: Reproductive / embryonic association Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 1 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. Verbeurgt Table S3 reports 0/26 donors at >=5 estimated copies per 20 ng RNA; the raw Cq <35 count is recorded separately. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Verbeurgt 2014: normal human olfactory-mucosa qPCR |
| OR9A1P | Other:Review | 0.02013 | 36.23 | Admission reasons: Reproductive / embryonic association | Translation qualification Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Translation review: the reference cannot supply a complete approved protein. Recorded failures: ambiguous_or_interrupted_sequence | designated_translation_incomplete | nonqualifying_transcript_biotype. | HPA normal-tissue RNA, IHC and protein-evidence record |
| OR9G1 | Other:Review | 0.008469 | 109.4 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Exact-copy olfactory expression is the principal normal-tissue question. Odorant responses in transfected cells establish receptor activity, not endogenous normal or tumor protein. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. The 2026 fetal nasal atlas reports 1 cells expressing this exact gene label at 7-12 post-conceptional weeks. These counts are not TPM, protein or copy-specific peptide evidence. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Durante Table 7 reports RNA in 5 adult human olfactory sensory neurons. Reported RNA in normal human olfactory sensory neurons. | HPA normal-tissue RNA, IHC and protein-evidence record · Mbouamboua 2026: fetal human nasal atlas · Durante 2020: adult human olfactory single-cell atlas · Single cell analysis of olfactory neurogenesis and differentiation in adult humans |
| OTOR | Other:Review | 0.02184 | 5021 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Human fetal cochlear cloning and mixed human/avian Northern evidence identify an inner-ear question; they do not establish adult human protein. Retain the stage-specific normal hold. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Human fetal cochlear cloning and human/avian Northern evidence require stage-specific adult human localization. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record · A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. |
| SCYGR2 | Other:Expression | 0.007395 | 42.99 | Admission reasons: Reproductive / embryonic association HPA assigns a hair-follicle-development RNA cluster and imports protein-existence evidence. This does not identify a tissue-specific endogenous peptide for the selected proteoform; exact normal protein localization remains unverified. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record |
| SCYGR8 | Other:Expression | 0.005652 | 110.1 | Admission reasons: Reproductive / embryonic association The former KRTAP28-8 name and predicted structural role identify a skin/hair question. Homology and recombinant products do not establish endogenous human hair expression; inspect the exact selected sequence. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. | HPA normal-tissue RNA, IHC and protein-evidence record |
| TAAR6 | Other:Review | 0.5432 | 71.26 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Human normal-brain RT-PCR supplies the existing hold. Separate exact human TAAR6 from rodent receptor studies and schizophrenia association. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Human normal-brain RT-PCR requires compartment and protein assessment; association with schizophrenia is not itself a toxicity finding. | HPA normal-tissue RNA, IHC and protein-evidence record · Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. |
| TAAR8 | Other:Review | 0.238 | 37.37 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Human and rodent expression experiments must be separated. Recombinant human TAAR8 surface expression in COS-7 cells verifies a construct, not normal human tissue production. The current HPA response contains no tissue-IHC antibody assay for this protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Mixed human/rodent receptor-family study supports a normal-expression concern; no cross-species or paralog substitution is accepted. | HPA normal-tissue RNA, IHC and protein-evidence record · Human TAAR8 and murine Taar8b signaling and expression (2014) · Trace amines: identification of a family of mammalian G protein-coupled receptors. |
| TAS2R42 | Other:Review | 0.04812 | 106.4 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge Gene-specific adult human skin RNA supplies a normal-expression hold. The skin paper does not establish TAS2R42-specific protein, and other TAS2R staining cannot be borrowed. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. Gene-specific TAS2R42 RNA is reported in normal adult human skin biopsies and donor skin RNA data. | HPA normal-tissue RNA, IHC and protein-evidence record · Personalized expression of bitter receptors in human skin (2018) |
| TGM6 | Other:Review | 0.05328 | 15.54 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge The neural/ataxia annotation and uncertain HPA neuronal staining require direct adult human localization; neither genetic disease nor rodent antibody experiments alone establish human protein. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins Spinocerebellar ataxia 35: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA35 patients commonly show upper limb involvement and torticollis. There is no cognitive impairment. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record · Protein-glutamine gamma-glutamyltransferase 6 — UniProtKB/Swiss-Prot 2026_03 |
| USP17L13 | Other:Review | 0.00769 | 20.71 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge The current HPA antibody is uncertain and shared. A 2026 influenza study uses A549 cancer cells, CRISPR activation and overexpression; cytokine induction there cannot establish normal lung-cell production. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record · USP17L13 and influenza replication in A549 cells (2026) |
| USP17L8 | Other:Review | 0.008196 | 18.98 | Admission reasons: Reproductive / embryonic association | Reviewed normal-cell knowledge The HPA reagent is shared with related copies and gives uncertain normal staining. USP17L2/DUB3 functional literature cannot be transferred to USP17L8; retain an exact-copy normal-expression hold. HPA's MS field is unavailable; it supplies no protein-negative measurement. No exact-symbol assay occurs in the qPCR table; this supplies no negative measurement. Ambiguous legacy names are not reassigned. Current HPA has positive normal staining with uncertain reagent reliability; it cannot establish exact protein production or absence. Positive normal-tissue HPA staining remains unresolved under uncertain antibody validation. | HPA normal-tissue RNA, IHC and protein-evidence record |